Antiatherosclerotic aminoethenyl furochromones

ABSTRACT

The present invention provides certain novel aminoethanyl furochromones which are useful for antiatherosclerotic purposes.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a divisional of co-pending application Ser. No. 378,700, filed May 17, 1982, now U.S. Pat. No. 4,438,274.

BACKGROUND OF THE INVENTION

The present invention provides novel anti-atherosclerotic aminoethenyl furochromones. The use and preparation of these compounds is described in U.S. Pat. No. 4,438,274, which is expressly incorporated by reference herein.

PRIOR ART

Extensive pharmacological uses for khellin and related substances are known, as indicated in Appendix A, Khellin analogs are also known in the art. See, e.g., U.S. Pat. No. 4,284,569 and the review by Mustafa, "furopyrans and Furopyrones," John Wiley and Sons, Inc., N.Y., N.Y. (1976) pages 102-159 and U.S. Pat. No. 2,680,119 which describes 6 and/or 7-substituted furochromones, i.e., alkyl, alkoxyalkyl, and phenylalkyl substituted compounds.

SUMMARY OF THE INVENTION

The present invention provides:

a furochromone of formula II

wherein R₇ is --CH₂ --R₁₁, wherein R₁₁ is hydrogen or C₁ -C₅ thioalkyl;

wherein R₈ is --CH═CH--NR₁₂ R₁₃ wherein R₁₂ and R₁₃, being the same or different, are C₁ -C₃ alkyl; and

wherein one of R₅ and R₆ is methoxy and the other is hydrogen or R₅ and R₆ are both methoxy.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The present invention particularly provides (2'E)-4,9-dimethoxy-6-[(methylthio)methyl]-7-(1',N,N-dimethylamino-ethen-2'-yl)-5M-furo[3,2-g]-benzopyran-5-one. 

I claim:
 1. A furochromone of formula II ##STR1## wherein R₇ is --CH₂ --R₁₁, wherein R₁₁ is hydrogen or C₁ -C₅ thioalkyl;wherein R₈ is --CH═CH--NR₁₂ R₁₃ wherein R₁₂ and R₁₃, being the same or different, are C₁ -C₃ alkyl; and wherein one of R₅ and R₆ is methoxy and the other is hydrogen or both R₅ and R₆ are methoxy.
 2. (2'E)-4,9-Dimethoxy-6-[(methylthio)methyl]-7-(1',N,N-dimethylamino-ethen-2'-yl)-5M-furo[3,2-g]-benzopyran-5-one, a furochromone according to claim
 1. 